SAMPLE PREPARATION MARKET ANALYSIS

Increasing interest in developing fast, cost-effective, and environment friendly sample preparation techniques, lead to develop new methods which eventually helps to minimize the extraction steps, reduce solvent consumption, and thereby automate the sample preparation system. Sample preparation is necessary to isolate the desired or targeted components from complex matrices, which most analytical instruments cannot handle directly. Sample preparation process which can greatly impact the accuracy of research and are responsible for the success of downstream applications, such as nucleic acid or protein isolation and purification, pipetting, and other liquid-handling requirements. Current sample preparation trend includes miniaturization, automation, high-throughput performance, ability of new sample preparation instruments to combine with existing analytical instruments and reduction in solvent volume and time. Moreover, continuous development in sample preparation and integration of new technology such as automated systems, would further drive the sample preparation market. For instance, integration of QuEChERS method in solid phase extraction allows simple and streamline sample preparation system for analysis of various pharmaceutical and veterinary drugs. Automated sample preparation eliminates human error, low sample purity, and sample contamination, allowing consistent result.

Global sample preparation market is estimated to be valued at USD 8.62 Bn in 2024 and is expected to exhibit a CAGR of 6.4% during the forecast period (2024-2031).

Figure 1. Global Sample Preparation Market Value (US$ Bn), by Region, 2024

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Rapid shift from manual to automated sample preparation methods is expected to drive growth of the global sample preparation market.

Increasing adoption of innovative technologies and high requirements for product development are propelling demand for automation in sample preparation instruments. Furthermore, automated sample preparation offer various advantages such high productivity, repeatability, and traceability. It also lowers operator’s health and safety risks by reducing exposure to hazardous chemicals such as Ammonia, Sulfuric Acid. and biological laboratory samples. Furthermore, customers prefer total framework solutions, instead of standalone workstations, as they offer integration of different sample preparation instruments at one place. Automated sample preparation enhances the productivity of a laboratory by minimizing the resource allocation for repetitive tasks such as sample extraction, filtration, weighing, dilution, and sample analysis.

Moreover, key players are focused on introducing innovative products in the sample preparation market, which is expected to drive growth of market. For instance, on May 18, 2022, Biotage, a manufacturing company of products for drug discovery, development, diagnostics, and analytical testing, launched the Biotage Extrahera HV-5000, an automated workstation dedicated to column-based sample preparation that is able to aspirate and dispense high volume samples. The system maintains the Extrahera family’s small footprint, intuitive software, and precision engineering for the uniform processing of samples. With its 4-channel pipette head, the new workstation is able to aspirate and dispense volumes of 250 – 5000 μL per channel, and offers Good laboratory practice (GLP) capability and support for solid-phase extraction (SPE) and supported liquid extraction (SLE) column formats.

Figure 2. Global Sample Preparation Market Share, By Product Type, 2024

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Increasing advancement in blood collection tools and growing research and development funding from various government and private organizations are expected to drive market growth.

Various government and private organizations are focusing on increasing research and development investment in clinical diagnostic, forensic, proteomics, and genomics research. Proper sample preparation is vital to obtain significant and accurate results. Moreover, increasing research and development (R&D) spending by various government and private organizations is expected to increase adoption of advanced sample preparation instruments over forecast period. For instance, The German Research Foundation (DFG) on March 2018, funded US$ 17.3 million to four new Germany-based sequencing centers. The funding will be used to conduct research in next-generation sequencing field. In April 2018, DNA Script, DNA Synthesis Company has received US$ 5.5 million in funding from European Commission and France-based investment bank, Bpifrance. The funding was provided as a part of subsidies and refundable advances of European Commission’s Horizon 2020 European Innovation Council program and Bpifrance's innovation development programs. DNA Script intends to make innovation in synthesis of Deoxyribonucleic acid (DNA) and Ribonucleic acid (RNA) using its proprietary enzymatic technology.

Global Sample preparation Market – Impact of Coronavirus (COVID-19) Pandemic

Since the COVID-19 virus outbreak in December 2019, the disease has spread to over 100 countries across the globe and the World Health Organization declared it a public health emergency on January 30, 2020.

The COVID-19 can affect the economy in three main ways: by directly affecting the production and demand of sample preparation, by creating disruptions in distribution channels, and through its financial impact on firms and financial markets. Due to nationwide lockdowns, several countries such as China, India, Saudi Arabia, the U.A.E., Egypt, and others are facing problems with regard to the transportation of sample from one place to another.

However, the COVID-19 pandemic had a positive impact on the global sample preparation market, owing to increased research and development of vaccines to prevent coronavirus. For instance, On August 16, 2021, The National Institutes of Health (NIH) had developed a new sample preparation method to detect SARS-Cov-2, the virus that causes COVID-19. The method bypasses extraction of the virus’ genetic RNA material, simplifying sample purification and potentially reducing test time and cost.

Recent Developments

• In November 2023, QIAGEN, a Germany-based international provider of sample and assay technologies, expanded its sample technology portfolio with the release of two new solutions aimed at assisting researchers in managing various materials such as bone, tissue, and soil samples. The company launched two products: TissueLyser III and RNeasy PowerMax Soil Pro Kit. The introduction of TissueLyser III highlights QIAGEN's unwavering commitment to continuously improving its automated sample preparation and analysis solutions.
• In September 2023, DPX Technologies, a manufacturer of laboratory consumables for sample preparation, announced business expansion. This expansion includes the development of new product lines for proteomics and genomics testing and the construction of a large storage facility.
• In October 2022, Waters Corporation, an analytical laboratory instrument and software company, introduced Extraction+ Connected Device, a new software-controlled product for the Waters Andrew+ Pipetting Robot that automates the preparation of biological, food, forensic, and environmental samples using solid phase extraction (SPE). The new Extraction+ Connected Device automates and documents SPE procedures, saving hours on sample preparation for biological, food, forensic, environmental, and clinical research applications.
• In June 2022, Hamilton, a medical equipment manufacturer, and Bionano Genomics, Inc., a genome analysis solution provider, announced a collaboration to create the Long String VANTAGE for the separation of Ultra High Molecular Weight (UHMW) DNA for optical genome mapping (OGM). The extraction of high-quality and abundant UHMW DNA is a critical precondition and initial step in Bionano's sample preparation methodology. UHMW DNA extraction is often done manually by highly skilled and experienced laboratory professionals, limiting the volume and application in regular sample preparation.

Global Sample preparation Market: Restraint

Expensive setup for sample preparation and shortage of skilled professionals to operate advanced sample preparation instruments may hinder the sample preparation market, during the forecast period. Sample preparation can be complex when analyzing the drugs in biological matrices, which requires highly skilled professionals to operate. In some of the primary steps of sample preparation such as drawing blood or excising tumor tissue and executing it into a plate or tube (from which it is accessible to the automated sample preparation system), requires a high level of skill. Moreover, limitations of sample preparation system varies with instrument type and sample. In most of the sample preparation processes, samples are usually fluids. Viscous samples require more time and precaution than standard samples. Forensic samples are among the difficult samples to process due to their limited quantity and chances of environmental exposure on the substrates, which contain polymerase chain reaction (PCR) inhibitors. Extracting required amount of sample and further preparing laboratory analysis using sample preparation instruments requires detailed knowledge of instrument handling and related consumables.

Key Players

Major players operating in the global sample preparation market include F. Hoffmann-La Roche AG, Bio-Rad Laboratories, Inc., Thermo Fisher Scientific Inc., Agilent Technologies, Inc., Danaher Corporation, Qiagen N.V., PerkinElmer, Inc., Illumina, Inc. and Merck KGaA.