Blow Fill Seal Technology Market

Blow Fill Seal Technology Market Outlook (2022-2032)

The global blow fill seal technology market is set to enjoy a valuation of US$ 3.0 billion in 2022 and further expand at a CAGR of 8.6% to reach US$ 7.0 billion by the end of 2032.

Contribution of blow fill seal accounted for nearly 3.3% of the global pharmaceutical packaging market at the end of 2022. BFS technology is used in pharmaceuticals, food and beverage, cosmetics and personal care, and other industries (chemicals, etc.).

The bottles, ampoules, pre-filled syringes, and vials, are used to fill ophthalmic, respiratory, injectable medications, wound care, and biologics are the main products produced using BFS technology.

Report Attributes	Details
Blow Fill Seal Technology Size (2021A)	US$ 2.7 Billion
Pharmaceutical Packaging Market (Parent)	US$ 91.4 Billion
Estimated Market Value (2022E)	US$ 3.0 Billion
Forecasted Market Value (2032F)	US$ 7.0 Billion
Global Market Growth Rate (2022-2032)	8.6% CAGR
North America Market Share (2022)	~40.39%
Europe Market Growth Rate (2022-2032)	~8.1% CAGR
United States Market Growth Rate (2022-2032)	~8.8% CAGR
Market Share of Top 3 Countries	~27.8%
Key Companies Profiled	Amanta Healthcare Ltd. Unither Pharmaceuticals Catalent, Inc. Curida AS Unipharma LLC Weiler Engineering, Inc. GlaxoSmithKline plc. Takeda Pharmaceuticals International AG Nephron Pharmaceuticals Corporation Horizon Pharmaceuticals, Inc. Brevetti Angela S.R.L. Recipharm AB

Historic to Forecast Fact Analysis

Blow fill seal technology is primarily used for sterile filling and sealing of a container. BFS technology is preferred as it ensures contamination-free filling at low costs. The use of BFS for aseptic filling allows precise filling and hence proves to be beneficial for unit-dose packaging of pharmaceuticals. These attributes of the BFS technology are fueling its demand across the globe.

Furthermore, regulatory bodies such as FDA and MHRA have laid stringent guidelines for filling ophthalmic and injectable drugs. These guidelines have resulted in surged demand for BFS technology across the globe. Thus, the BFS technology market is anticipated to have a highly positive outlook in the years to come.

• Short Term (2022 Q2 to 2025): Boosting utilization and incorporation of blow fill seal technology in the food and beverage, chemicals and cosmetics industry will positively impact blow fill seal technology market growth.
• Medium Term (2025-2028): Europe and Asia Pacific are anticipated to witness high blow fill seal technology demand on the back of the growing pharmaceutical industry in the region.
• Long Term (2028-2032): Increasing pharmaceutical industry and continuous innovation in blow fill seal technology will drive the market in the long term.

Over the 2017-2021 historical period, the global blow fill seal technology market registered a CAGR of 7.5%, and according to the Fact.MR, a market research and competitive intelligence provider, the market is projected to exhibit growth at 8.6% CAGR between 2022 and 2032.

Market share analysis of blow fill seal technology based on application and region is provided in a nutshell in the above image. Under the end-use segment, the pharmaceutical sub-segment dominates with 97.7% market share in 2022.

“BFS technology in the pharmaceutical, household and food industries hitting predicted CAGRs”

BFS, an advanced sterilization technology, is used to minimize human operational interventions and also to reduce the risk of contamination in filling and packaging liquid drugs.

Food & beverages (especially baby food), cosmetics, liquid adhesives, food supplements, machine oils, and pheromones can be easily carried in BFS containers, bottles, or packs. These offer a high degree of flexibility for container design, customized sizes, and their openings, as per their use, through blow molding techniques.

The reason for having a wide range of applications in various industries is because BFS minimizes human interference and diminishes the probability of introducing microbial pollution and foreign particulate matter in the manufacturing process.

“Blow Fill Seal Technology Aids in Curbing Medical Non-Adherence Issues”

Poor medical adherence has been a significant problem for the healthcare sector for the past three decades since it puts patient safety at risk and escalates healthcare expenses. The healthcare sector continuously makes considerable attempts to improve the usage of medications by creating novel drug delivery systems and packaging to ensure the patient receives the proper dose at the appropriate time.

• According to a study by IMS Health, the improper use of medications by patients costs the U.S. healthcare system more than 210 billion dollars annually. Due to such situation, there is now a desire for pharmaceutical goods that have precisely calibrated doses, are simple to use, and offer patients some amount of comfort.

Pharmaceutical firms use blow fill seal technology extensively to produce unit dose packaging solutions as a way to increase patient adherence to recommended treatment regimes. Additionally, due to the protective packaging, packaging medication in a single dose using blow fill seal technology offers higher drug accuracy and a decrease in drug contamination. Medication non-adherence poses a serious risk to patient’s health, creates huge waste in the healthcare system, and increases costs because of subpar patient results.

The pharmaceutical industry is concentrating on essential formulations, forms, and packaging strategies to deliver safer and more effective pharmaceuticals to patients around the world because of the expectation of better health outcomes in real-world use.

“High Regulatory Scrutiny of the Industry: A Major Challenge to Aseptic Manufacturers”

The greatest challenge faced by aseptic product manufacturers is the high regulatory scrutiny of the industry. Moreover, manufacturing companies are also seeing growth in the number of customers who are approaching them with compliance challenges.

They are demanding testing and analysis even beyond regulatory requirements to have a deeper understanding of the possible risks associated with impurities coming in contact with a drug. Similarly, the trend towards smaller batches for smaller patient populations is driving down the number of vials that may be required for a particular product, meaning facilities need to be able to adapt to quick turnaround times and be nimble in managing new product introductions.

Another challenge faced by manufacturers in developed countries such as Germany and the Netherlands is tough price competition, which has been worsened by the introduction of tenders and has also led to discounting of more than 95% on some products.

Country-wise Insights

Will the Pharmaceutical Sector in the U.S. Drive High Demand for Blow Fill Seal Technology?

The United States BFS technology market is currently estimated at US$ 989.8 million and is expected to reach US$ 2,224.1 million by 2032.

The demand for BFS technology in the region is mainly driven by the rising demand for biotechnology-derived drugs as well as new bio-manufacturing formats. These niche drugs require flexible filling solutions for the accommodation of different batch sizes which can be achieved by using BFS technology.

Manufacturers in the region are expanding their production capacity as well as product offerings by the acquisition of small-scale players. The established healthcare sector in the region is anticipated to represent a steady demand for BFS technology in the years to come and expand by 2.2X its current value by 2032.

Why is the Germany Blow Fill Seal Technology Expected to Be Highly Lucrative?

Germany is one of the top pharmaceutical producers and largest exporters of medicinal products in the world. Germany is anticipated to remain the target region for the blow fill seal technology manufacturers, with pharmaceutical packaging giants having their bases setup in the region, and they prefer choosing blow fill seal technology for their sterile ampoule and injectable packaging.

Additionally, injectable packaging has remained the primary focus of companies operating in the region which is driving the market.

The Germany market for blow fill seal technology is expected to reach a valuation of US$ 193.1 million in 2022.

Category-wise Insights

Why is PE BFS technology Most Widely Used?

Attributes such as easy availability, non-reactivity at room temperature, and excellent barrier properties offered by polyethylene material are likely to drive the demand for the segment during the forecast period.

The most popular product type PE has remained the primary material of choice among the blow fill seal technology end-users. With the substantial traction for sterile pharmaceutical packaging gaining traction, blow fill seal technology has remained the favorite choice of packaging among manufacturers.

Furthermore, LDPE accounts for more than 60% of the PE used in the BFS technology market and is projected to maintain its lead in the global market, growing at a CAGR of 7.9% during 2022-32.

Will Market Growth Be Led by Pharmaceutical Industry?

Applications for BFS technology can be found in many different sectors. But the pharmaceutical business continues to be its biggest consumer. The pharmaceuticals segment is witnessing significant growth over the past two years. To produce hygienic and aseptic packing products in a regulated environment without any additional interruption of foreign particles, advancements like BFS technology are used.

Co-extrusion technology uses a combination of up to seven layers and is specifically used for delicate products like injectable pharmaceuticals that are sensitive to oxygen and carbon dioxide.

Growing demand for non-contaminated drug formulations and the increased demand for single dosage packaging, for reference prefilled syringes, is accelerating the demand for the market in pharmaceutical sectors.

The pharmaceutical segment is expected to account for more than 98% share by 2032 end.

Competitive Landscape

Market’s prominent manufacturers are Amanta Healthcare Ltd, Unither Pharmaceuticals, Pharmapack Co. Ltd, Catalent, Inc., Curida AS, Unipharma LLC, Weiler Engineering, Inc., GlaxoSmithKline plc., Takeda Pharmaceuticals International AG, Nephron Pharmaceuticals Corporation, Horizon Pharmaceuticals, Inc., Brevetti Angela S.R.L., and Recipharm AB.

The manufacturers are partnering with pharmaceutical players and are providing contract manufacturing services for their ampoules and prefilled syringes and injectable. Supplementing production, capacity expansion, upgrading, and enhancing their operational efficiency have remained the primary focus of technology providers. Additionally, collaboration remains the go-to strategy seen among the manufacturers trying to expand their geographical presence.

• In Dec 2021, Woodstock was granted a US patent for their Cold BFS system. In this process, optimal temperature is controlled to prevent heat related damage and is ideal for medicines that are susceptible to heat.
• In Jan. 2021, Berry Global Healthcare launched Cyrano, their lightest blow fill seal closure. It was designed to reduce plastic usage and provide an easy solution to all intravenous and infusion systems.

Fact.MR has provided detailed information about the price points of key manufacturers of blow fill seal technology positioned across regions, sales growth, production capacity, and speculative technological expansion, in the recently published report.

Segmentation of Blow Fill Seal Technology Industry Research

• By Product Type :

  • Bottles
    • 0.2-100ml
    • 100-500ml
    • Above 500ml
  • Ampoules
    • 0.1-10ml
    • 10-100ml
  • Vials
    • 0.1-10ml
    • 10-50ml
  • Prefilled Syringes & Injectable

• By Material Type :

  • PE
    • LDPE
    • HDPE
  • PP
  • Others (EVOH etc.)

• By End-Use :

  • Pharmaceuticals
    • Ophthalmic
    • Injectable
    • Biologics
    • Wound Care
    • Respiratory Therapy
  • Food & Beverages
  • Cosmetics & Personal Care
  • Others (Chemicals etc.)

• By Region :

  • North America
  • Latin America
  • Europe
  • East Asia
  • South Asia & Oceania
  • MEA